With Germany and Portugal expected to both qualify out of the group in Group G, Ghana will have to pull off a bit of a shock to reach the Second Round of the 2014 World Cup.
Should they progress at the expense of one of the European sides, Ghana's next target would surely be to match 2010's performance - as they reached the quarter-finals to be named the Top African team in South Africa.
HOW GHANA GOT TO THE 2014 WORLD CUP
Entering AFC Qualifying in the Second Round, Ghana topped Group D to progress to the Playoff stage.
Seemingly given the trickiest of ties against Egypt, Ghana strolled to a 7-3 aggregate win - following a 6-1 home win in the first leg - to book their place in Brazil for the 2014 World Cup.
GHANA MANAGER AND TRACK RECORD
After winning the 2011 All-Africa games with the Under-23s, former Ghanaian International Akwasi Appiah was named as manager of the main side the following April.
Reaching the Second Round in their debut appearance in 2006, Ghana then progressed to the quarter-finals four years later. However, they were denied a place in the last-four by Luis Suarez's handball on the line, which ultimately saw Uruguay progress after penalties.
GHANA KEY PLAYER
Representing Ghana in their previous two World Cup appearances, captain Asamoah Gyan will be looking to exorcise some demons this summer - after his penalty miss against Uruguay ultimately cost his country a place in the 2010 World Cup Semi-finals.
The 28-year-old has scored 39 times in 76 appearances for the Black Stars - including three goals during the tournament in South Africa, which was enough to see Sunderland bring him to the Premier League.
Despite moving on to Al-Ain in the UAE, Gyan is still Ghana's main attacking threat and his past failings will surely give him the hunger to perform to his best in Brazil this summer.
GHANA 2014 WORLD CUP BETTING TIP
Placed into a difficult Group G, Ghana will need to be at their very best to stop one of Germany or Portugal reaching the Second Round.
The battle for the wooden spoon between themselves and the USA is too close to call, so avoid predicting specific finishing spots and just back Ghana to fail to qualify from Group G.
GHANA 2014 WORLD CUP SQUAD
Goalkeepers: Adam Larsen Kwarasey, Fatau Dauda, Stephen Adams.
Defenders: Samuel Inkoom, Daniel Opare, Harrison Afful, Jeffery Schlupp, John Boye, Jonathan Mensah, Rashid Sumaila, Jerry Akaminko.
Midfielders: Michael Essien, Sulley Ali Muntari, Rabiu Mohamed, Kwadwo Asamoah, Emmanuel Agyemang Badu, Afriyie Acquah, Christian Atsu, Albert Adomah, Andre AyeW, Mubarak Wakaso, David Accam.
Forwards: Asamoah Gyan, Kevin Prince Boateng, Abdul Majeed Waris, Jordan Ayew.