Making their seventh consecutive appearance at a World Cup, the USA will do well to qualify out of the group for a fourth time in Brazil.
The 2014 World Cup betting markets back Germany and Portugal to progress in Group G, which would prevent the USA from reaching the Second Round in back-to-back tournaments.
HOW USA GOT TO THE 2014 WORLD CUP
Progressing directly in the CONCACAF Third Round with a bye, the USA topped Group A ahead of Jamaica - as they both progressed into the Fourth Round.
With three automatic qualification spots up for grabs, USA finished top of the six-team group with 22 points - accumulating twice as many points as fourth-placed Mexico, who had to settle for a Playoff spot.
USA MANAGER AND TRACK RECORD
After leading Germany into their home tournament in 2006, Jurgen Klinsmann will return to the World Cup finals as manager of the USA.
The five-time CONCACAF Gold Cup champions have qualified for every World Cup tournament since 1990, with their best performance coming in 2002 - as they reached the quarter-finals.
USA KEY PLAYER
Versatile USA captain Clint Dempsey has a keen eye for goal and often finds the back of the net from long range.
Known for his resiliance and his toughness, the 31-year-old has scored 36 goals in 101 appearances for his country and will be representing the USA in his third World Cup finals.
Returning to former club Fulham on loan in the second half of this season, the Seattle Sounders midfielder will arrive in Brazil looking to inspire the his side to upset the odds in Group G.
USA 2014 WORLD CUP BETTING TIP
United States will have to see off one of Germany and Portugal as well as Ghana if they are to qualify out of the group at the 2014 World Cup in Group G.
Despite reaching the Second Round four years ago, United States were beaten in the last-16 by Ghana. So, while they have a chance of revenge for that loss, expect United States to be eliminated in the Group Stage for the fourth time in their World Cup history.
USA 2014 WORLD CUP SQUAD
Goalkeepers: Brad Guzan, Tim Howard, Nick Rimando.
Defenders: DaMarcus Beasley, Matt Besler, John Brooks, Geoff Cameron, Timmy Chandler, Omar Gonzalez, Fabian Johnson, DeAndre Yedlin.
Midfielders: Kyle Beckerman, Alejandro Bedoya, Michael Bradley, Brad Davis, Mix Diskerud, Julian Green, Jermaine Jones, Graham Zusi.
Forwards: Jozy Altidore, Clint Dempsey, Aron Johannsson, Chris Wondolowski.