Bookmakers have each of these nations as outsiders to qualify from Group G, so Ghana v USA looks to be a must win game for both sides in their opening match of the tournament in Natal.
Ghana are slight favourites to get their campaign off to a good start, but there looks to be little between the sides and USA's winning mentality makes them an appealing bet in the match odds market. With such a close game expected there could be an opportunity to play the Winning Margin market as a single goal could well be the difference in this match, while a Correct Score bet of 1-0 to USA will bring punters a decent return.
Clint Dempsey looks an obvious candidate for any goal-scorer bets on the game with the Stars and Stripes likely to rely heavily on his knack of finding the net. Jozy Altidore has not been firing with any consistency for Sunderland this season, but Landon Donovan makes an interesting alternative at potentially longer odds given his record for USA. Should Ghana find the net then Asamoah Gyan is likely to be the scorer and he is a sensible bet, with Sully Ali Muntari the best alternative given his goal-scoring record from midfield.
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