Online bookmakers are offering free bets to new customers as Sir Alex Ferguson attempts to lead the Red Devils to a record-breaking 19th top flight title this season.
Barclays Premier league second favourites Manchester United are available at odds of 23/10 with Irish bookie Paddy Power and are expected to get off to a comfortable winning start against the Coca Cola champions tonight.
The visiting Toon Army will harbour dreams of a repeat 1-1 draw achieved when the Magpies stole a point on their last visit two seasons ago. Optimists will be able to secure odds of 12/1 with 888 Sport for the same score line.
Manchester United have looked very sharp in pre-season culminating with victory over Chelsea in the Community Shield and should have little trouble disposing of Chris Hughton’s weak looking side.
Sir Alex has a plenty of options available to him and must decide if he should change the starting side that beat Chelsea 3-1.
He could stay with Michael Owen up front who is 5/1 with 888 Sport to score the first goal against his former side.
Alternatively he may choose to give a start to Javier Hernadez or Dimitar Berbatov who both came on as subs to score at Wembley.
On the injury front Patrice Evra is available to replace Fabio at left back having recovered from his leg injury.
Central defender Rio Ferdinand along with midfielders Owen Hargreaves and Anderson will remain sidelined until next month at soonest.
Newcastle striker Andy Carroll has trained since suffering a back injury against Rangers and makes the starting line up as should midfielder Alan Smith who had an ankle knock.
Forward Leon Best is missing with an ankle injury and Shola Ameobi will be on the bench as cover for lone striker Carroll.
Hughton will be without central defenders Sol Campbell, who is not match fit, and Steven Taylor who has a shoulder injury.
Other absentees are full back Danny Simpson who misses the chance to face his former club and new signing Dan Gosling has a long term knee injury.
Possible starting line ups:
MAN UTD: Van der Sar, O’Shea, Vidic, Evans, Evra, Scholes, Carrick, Park, Valencia, Rooney, Owen.
NEWCASTLE UTD: Harper, Perch, Taylor, Coloccini, Gutierrez, Nolan, Barton, Guthrie, Routledge, Carroll, Smith.