Reigning Premier League Champions Manchester will provide Arsenal with the sternest test of their title credentials when the pair go head-to-head on September 13th.
The Gunners, who have again opened the cheque book this season with the arrival of Barcelona's Alexis Sanchez, know they will need to be at their best to defeat City.
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Returning to the head-to-head record between Arsenal and Man City, the Citizens have lost just two of the last 10 meetings between the two clubs in the League.
And Arsenal's Premier League victory against City was back in April 2012 when Mikel Arteta scored a brilliant 87th minute striker to snatch the victory.
Last season, Mathiue Flamini's effort cancelled out David Silva's opener as the two sides played out a 1-1 draw at the Emirates.
While City picked up a memorable 6-3 win over The Gunners' at the Etihad Stadium in December.
Arsenal have already shown they can beat City this year, however, with a ruthless 3-0 victory over Manchester men in the Community Shield in August.
The 2014/15 curtain raiser between the Premier League and FA Cup winners was a thoroughly one-sided affair with Santi Cazorla, Aaron Ramsey and Olivier Giroud all on target.
Arsene Wenger's men look like a side with a weight off their shoulders this year following their FA Cup final victory over Hull City in May.
The triumph ended the Londoner's nine-year weight for silverware and the arrivals of Sanchez, Mathieu Debuchy and Calum Chambers have further strengthed the side.
Injuries curtailed their title bid last season with Ramsey's the one that was felt the most and the Welshman has begun the new campaign in fantastic form once again.
Netting against City in the Community Shield final, he was also on target against Crystal Palace and Everton.
He is always worth a bet in the goalscorer market, as is City's
Silva who has netted in three of the last six Premier League meetings between the two sides.
The Spanish International started the season with a goal against Newcastle on the opening day and he will be looking to continue his great record against Arsenal at the Emirates.
Seven of the last eight Premier League meetings between the two have produced fewer than 2.5 goals, meanwhile, with the exception being City's incredible 6-3 win last season.
Arsenal put three past the City defence in the Community Shield as well but that was against a back-four that was missing leader Vincent Kompany.
The Belgium international's presence will strengthen the Man City defence and a repeat of August's performance is unlikely from City who will also have no.1 Joe Hart back in goal.