The home nation looks to build on a great start to their Gold Cup campaign in the first in a double-header at Rio Tinto Stadium in Utah, watch USA v Cuba live stream at 20:30 (BST) on Saturday 13th July.
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The 2011 finalists hammered six goals for the second time in less than a week when defeating Belize 6-1 in Portland on Wednesday having hit Guatemala for six in their warm up game last Friday.
Main rivals, Mexico, slipped to a 2-1 defeat against Panama in their first game on opening night at the Rose Bowl in Pasedena and USA are now odds-on favourite to win the Gold Cup for the fifth time.
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Cuba lost 3-0 against Costa Rica in Pasedena and it will be a major shock if Jurgen Klinnsman’s side fail to secure three points against the Group C minnows.
The nations last met in a World Cup qualifier in 2008 when USA routed the Cubans 6-1. LA Galaxy star Landan Donovan was among the USA scorers that day and will be looking to the goal he scored against Belize in the opener.
Costa Rica will be expected to run out comfortable winners against Belize in the second game at the Rio Tinto which kicks off at 23:00 BST on Saturday.