49ers v Rams Tips: Thursday Night Football Picks & Betting Offers

Week 15 of the 2024 NFL season kicks off with an NFC West clash on Thursday Night Football. The 7-6 Los Angeles Rams take on the 6-7 San Francisco 49ers at Levi’s Stadium in Santa Clara, and we’ve compiled our Rams v 49ers tips in the form of a bet builder.
This is the second meeting between Los Angeles and San Francisco this season. The Rams edged out the 49ers 27-24 as six-point home underdogs in Week 3. This time, the Niners are listed as 2.5-point home favourites by leading UK betting sites, with the total set at 49.5 points.
49ers v Rams Tips: 7/2 Bet Builder for Thursday Night Football
We've put together our 49ers v Rams bet builder using Betfair, renowned as one of the best NFL betting sites for its extensive range of markets.
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Kyren Williams Anytime Touchdown Scorer
The Rams overcame a 14-point deficit in Week 3, securing victory over the 49ers with a late field goal. Kyren Williams was instrumental for Los Angeles, delivering 24 carries for 89 yards and two touchdowns while adding two receptions for 27 yards and another score.
Williams has been exceptional this season. The fifth-round pick from the 2022 NFL Draft has accumulated 1,168 yards from scrimmage and 14 touchdowns across 13 games. In their thrilling 44-42 win over the Buffalo Bills last week, Williams carried the ball 29 times for 87 yards and two touchdowns.
With this in mind, we begin our 49ers v Rams tips by backing Williams to score a touchdown. He has found the end zone in each of his last three games, and the Rams will continue to rely heavily on their lead running back.
The 49ers concede 23.7 points per game (21st in the NFL) and have allowed the second-most rushing touchdowns in the league (19). Their defence ranks 31st in red-zone efficiency (72.1%).
Although San Francisco dominated the Chicago Bears 38-13 last week, limiting them to just 68 rushing yards, the Bears’ running game is among the weakest in the league. Over the last four weeks, the 49ers have surrendered eight rushing touchdowns, making Kyren Williams well-positioned for another impressive performance.
Jauan Jennings Anytime Touchdown Scorer
Jauan Jennings delivered an outstanding performance during the 49ers' 27-24 loss to the Rams in Week 3. The 27-year-old wide receiver caught 11 of his 12 targets, amassing an impressive 175 yards and three touchdowns—arguably the best game of his career.
Jennings is enjoying a breakout season, leading San Francisco in targets (78) and receptions (57). He’s second on the team in both receiving yards (774) and receiving touchdowns (6).
In Week 14, the 49ers dominated the Chicago Bears, with Jennings at the forefront, securing seven receptions for 90 yards and two touchdowns. Over his last four games, he’s found the end zone twice, including a ten-catch, 91-yard outing with a touchdown against the Seattle Seahawks in Week 11.
The Rams concede 25.5 points per game (24th in the NFL) and have allowed 36 offensive touchdowns this season, 23 of which have been through the air. Opposing wide receivers have accounted for 17 touchdowns against the Rams, placing them among the most generous defences in this category.
Los Angeles’ defence has been inconsistent throughout the season. The Rams rank 24th in passing yards allowed per game (225.1) and 30th in yards per pass completion (12.2). Last week, they allowed Josh Allen to throw for 342 yards and three touchdowns. Jennings is well-positioned to capitalise on this shaky defence and further bolster his impressive season stats.
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Dusan Jovanovic
Over the past ten years, Dusan has specialised in analysing and handicapping various sports leagues, including the NFL, MLB, NCAA Football, NCAA Basketball, NBA, NHL, and numerous European football leagues.